The effects of meldonium on the acute ischemia/reperfusion liver injury in rats
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2021
Аутори
Đurašević, Siniša![](/themes/Mirageriofh/images/orcid.png)
Stojković, Maja
![](/themes/Mirageriofh/images/orcid.png)
Sopta, Jelena
Pavlović, Sladan
Borković-Mitić, Slavica
![](/themes/Mirageriofh/images/orcid.png)
Ivanović, Andelija
Jasnić, Nebojša
![](/themes/Mirageriofh/images/orcid.png)
Tosti, Tomislav
![](/themes/Mirageriofh/images/orcid.png)
Đurović, Saša
![](/themes/Mirageriofh/images/orcid.png)
Đorđević, Jelena
Todorović, Zoran
![](/themes/Mirageriofh/images/orcid.png)
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/d...ehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.
Извор:
Scientific Reports, 2021, 11, 1Издавач:
- Nature Portfolio
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200178 (Универзитет у Београду, Биолошки факултет) (RS-MESTD-inst-2020-200178)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200051 (Институт за општу и физичку хемију, Београд) (RS-MESTD-inst-2020-200051)
DOI: 10.1038/s41598-020-80011-y
ISSN: 2045-2322
PubMed: 33446709
WoS: 000626774100019
Scopus: 2-s2.0-85099371879
Институција/група
Institut za opštu i fizičku hemijuTY - JOUR AU - Đurašević, Siniša AU - Stojković, Maja AU - Sopta, Jelena AU - Pavlović, Sladan AU - Borković-Mitić, Slavica AU - Ivanović, Andelija AU - Jasnić, Nebojša AU - Tosti, Tomislav AU - Đurović, Saša AU - Đorđević, Jelena AU - Todorović, Zoran PY - 2021 UR - https://riofh.iofh.bg.ac.rs/handle/123456789/798 AB - Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures. PB - Nature Portfolio T2 - Scientific Reports T1 - The effects of meldonium on the acute ischemia/reperfusion liver injury in rats IS - 1 VL - 11 DO - 10.1038/s41598-020-80011-y UR - conv_915 ER -
@article{ author = "Đurašević, Siniša and Stojković, Maja and Sopta, Jelena and Pavlović, Sladan and Borković-Mitić, Slavica and Ivanović, Andelija and Jasnić, Nebojša and Tosti, Tomislav and Đurović, Saša and Đorđević, Jelena and Todorović, Zoran", year = "2021", abstract = "Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.", publisher = "Nature Portfolio", journal = "Scientific Reports", title = "The effects of meldonium on the acute ischemia/reperfusion liver injury in rats", number = "1", volume = "11", doi = "10.1038/s41598-020-80011-y", url = "conv_915" }
Đurašević, S., Stojković, M., Sopta, J., Pavlović, S., Borković-Mitić, S., Ivanović, A., Jasnić, N., Tosti, T., Đurović, S., Đorđević, J.,& Todorović, Z.. (2021). The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. in Scientific Reports Nature Portfolio., 11(1). https://doi.org/10.1038/s41598-020-80011-y conv_915
Đurašević S, Stojković M, Sopta J, Pavlović S, Borković-Mitić S, Ivanović A, Jasnić N, Tosti T, Đurović S, Đorđević J, Todorović Z. The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. in Scientific Reports. 2021;11(1). doi:10.1038/s41598-020-80011-y conv_915 .
Đurašević, Siniša, Stojković, Maja, Sopta, Jelena, Pavlović, Sladan, Borković-Mitić, Slavica, Ivanović, Andelija, Jasnić, Nebojša, Tosti, Tomislav, Đurović, Saša, Đorđević, Jelena, Todorović, Zoran, "The effects of meldonium on the acute ischemia/reperfusion liver injury in rats" in Scientific Reports, 11, no. 1 (2021), https://doi.org/10.1038/s41598-020-80011-y ., conv_915 .