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The effects of meldonium on the acute ischemia/reperfusion liver injury in rats
dc.creator | Đurašević, Siniša | |
dc.creator | Stojković, Maja | |
dc.creator | Sopta, Jelena | |
dc.creator | Pavlović, Sladan | |
dc.creator | Borković-Mitić, Slavica | |
dc.creator | Ivanović, Andelija | |
dc.creator | Jasnić, Nebojša | |
dc.creator | Tosti, Tomislav | |
dc.creator | Đurović, Saša | |
dc.creator | Đorđević, Jelena | |
dc.creator | Todorović, Zoran | |
dc.date.accessioned | 2023-06-01T10:28:40Z | |
dc.date.available | 2023-06-01T10:28:40Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://riofh.iofh.bg.ac.rs/handle/123456789/798 | |
dc.description.abstract | Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures. | en |
dc.publisher | Nature Portfolio | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200178/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200168/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200110/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200051/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | The effects of meldonium on the acute ischemia/reperfusion liver injury in rats | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.issue | 1 | |
dc.citation.other | 11(1): - | |
dc.citation.rank | M21 | |
dc.citation.volume | 11 | |
dc.identifier.doi | 10.1038/s41598-020-80011-y | |
dc.identifier.fulltext | http://riofh.iofh.bg.ac.rs/bitstream/id/371/795.pdf | |
dc.identifier.pmid | 33446709 | |
dc.identifier.rcub | conv_915 | |
dc.identifier.scopus | 2-s2.0-85099371879 | |
dc.identifier.wos | 000626774100019 | |
dc.type.version | publishedVersion |