Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System
2023
Аутори
Stolić-Jovanović, AleksandraMartinović, Milica
Zugić, Ana
Nešić, Ivana
Tosti, Tomislav
Blagojević, Stevan
Tadić, Vanja M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The dual controlled release of emulgels makes them efficient drug delivery systems of increasing interest. The framework of this study was to incorporate selected L-ascorbic acid derivatives into emulgels. From the formulated emulgels, the release profiles of actives were evaluated considering their different polarities and concentrations, and consequently their effectiveness on the skin via a long-term in vivo study that lasted for 30 days was determined. Skin effects were assessed by measuring the electrical capacitance of the stratum corneum (EC), trans-epidermal water loss (TEWL), melanin index (MI) and skin pH. In addition, the sensory and textural properties of emulgel formulations were compared with each other. The changes in the rate of the release of the L-ascorbic acid derivatives were monitored using the Franz diffusion cells. The obtained data were statistically significant, and indicated an increase in the degree of hydration of the skin and skin whitening potential, while... no significant changes in TEWL and pH values were detected. The consistency, firmness and stickiness of the emulgels were estimated by volunteers applying the established sensory evaluation protocol. In addition, it was revealed that the difference in hydrophilic/lipophilic properties of L-ascorbic acid derivatives influenced their release profiles without changing their textural characteristics. Therefore, this study highlighted emulgels as L-ascorbic acid suitable carrier systems and one of the promising candidates as novel drug delivery systems.
Кључне речи:
texture and sensory analysis / magnesium ascorbyl phosphate / L-ascorbic acid / in vivo study / Franz diffusion cell / emulgel / ascorbyl palmitateИзвор:
Pharmaceutics, 2023, 15, 3Издавач:
- MDPI AG
Финансирање / пројекти:
- E!13632
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200113 (Универзитет у Нишу, Медицински факултет) (RS-MESTD-inst-2020-200113)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200003 (Институт за проучавање лековитог биља 'Др Јосиф Панчић', Београд) (RS-MESTD-inst-2020-200003)
DOI: 10.3390/pharmaceutics15030813
ISSN: 1999-4923
PubMed: 36986679
WoS: 000959777200001
Scopus: 2-s2.0-85151355118
Институција/група
Institut za opštu i fizičku hemijuTY - JOUR AU - Stolić-Jovanović, Aleksandra AU - Martinović, Milica AU - Zugić, Ana AU - Nešić, Ivana AU - Tosti, Tomislav AU - Blagojević, Stevan AU - Tadić, Vanja M. PY - 2023 UR - https://riofh.iofh.bg.ac.rs/handle/123456789/987 AB - The dual controlled release of emulgels makes them efficient drug delivery systems of increasing interest. The framework of this study was to incorporate selected L-ascorbic acid derivatives into emulgels. From the formulated emulgels, the release profiles of actives were evaluated considering their different polarities and concentrations, and consequently their effectiveness on the skin via a long-term in vivo study that lasted for 30 days was determined. Skin effects were assessed by measuring the electrical capacitance of the stratum corneum (EC), trans-epidermal water loss (TEWL), melanin index (MI) and skin pH. In addition, the sensory and textural properties of emulgel formulations were compared with each other. The changes in the rate of the release of the L-ascorbic acid derivatives were monitored using the Franz diffusion cells. The obtained data were statistically significant, and indicated an increase in the degree of hydration of the skin and skin whitening potential, while no significant changes in TEWL and pH values were detected. The consistency, firmness and stickiness of the emulgels were estimated by volunteers applying the established sensory evaluation protocol. In addition, it was revealed that the difference in hydrophilic/lipophilic properties of L-ascorbic acid derivatives influenced their release profiles without changing their textural characteristics. Therefore, this study highlighted emulgels as L-ascorbic acid suitable carrier systems and one of the promising candidates as novel drug delivery systems. PB - MDPI AG T2 - Pharmaceutics T1 - Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System IS - 3 VL - 15 DO - 10.3390/pharmaceutics15030813 UR - conv_1095 ER -
@article{ author = "Stolić-Jovanović, Aleksandra and Martinović, Milica and Zugić, Ana and Nešić, Ivana and Tosti, Tomislav and Blagojević, Stevan and Tadić, Vanja M.", year = "2023", abstract = "The dual controlled release of emulgels makes them efficient drug delivery systems of increasing interest. The framework of this study was to incorporate selected L-ascorbic acid derivatives into emulgels. From the formulated emulgels, the release profiles of actives were evaluated considering their different polarities and concentrations, and consequently their effectiveness on the skin via a long-term in vivo study that lasted for 30 days was determined. Skin effects were assessed by measuring the electrical capacitance of the stratum corneum (EC), trans-epidermal water loss (TEWL), melanin index (MI) and skin pH. In addition, the sensory and textural properties of emulgel formulations were compared with each other. The changes in the rate of the release of the L-ascorbic acid derivatives were monitored using the Franz diffusion cells. The obtained data were statistically significant, and indicated an increase in the degree of hydration of the skin and skin whitening potential, while no significant changes in TEWL and pH values were detected. The consistency, firmness and stickiness of the emulgels were estimated by volunteers applying the established sensory evaluation protocol. In addition, it was revealed that the difference in hydrophilic/lipophilic properties of L-ascorbic acid derivatives influenced their release profiles without changing their textural characteristics. Therefore, this study highlighted emulgels as L-ascorbic acid suitable carrier systems and one of the promising candidates as novel drug delivery systems.", publisher = "MDPI AG", journal = "Pharmaceutics", title = "Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System", number = "3", volume = "15", doi = "10.3390/pharmaceutics15030813", url = "conv_1095" }
Stolić-Jovanović, A., Martinović, M., Zugić, A., Nešić, I., Tosti, T., Blagojević, S.,& Tadić, V. M.. (2023). Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System. in Pharmaceutics MDPI AG., 15(3). https://doi.org/10.3390/pharmaceutics15030813 conv_1095
Stolić-Jovanović A, Martinović M, Zugić A, Nešić I, Tosti T, Blagojević S, Tadić VM. Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System. in Pharmaceutics. 2023;15(3). doi:10.3390/pharmaceutics15030813 conv_1095 .
Stolić-Jovanović, Aleksandra, Martinović, Milica, Zugić, Ana, Nešić, Ivana, Tosti, Tomislav, Blagojević, Stevan, Tadić, Vanja M., "Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System" in Pharmaceutics, 15, no. 3 (2023), https://doi.org/10.3390/pharmaceutics15030813 ., conv_1095 .